|Place of Origin:||China|
Payment & Shipping Terms:
|Minimum Order Quantity:||10 vials|
|Packaging Details:||foil bag or box|
|Delivery Time:||3-7 working days after the payment of order|
|Payment Terms:||Western Union, MoneyGram, T/T,Bitcoin|
|Supply Ability:||100000 vials|
Sermorelin CAS 86168-78-7 Muscle Building Sterods Growth Hormone Releasing Hormones
Also called as GRF 1-29, Sermorelin is GHRH derivative that contains first, active 29 amino acids chain of GHRH that promote release of growth hormones from the pituitary. Sermorelin forms the shortest 1-29 fragment, yet completely functional fragment of GHRH. Increased levels of Sermorelin are linked with augmentation of lean muscular tissues, improved immunological functions, bone density and reduced adipose tissue fat. As Sermorelin increase release of hGH and Insulin-like Growth factor-1, the molecule is being studied as a potential anti-aging tool. Research studies have confirmed that 29 amino acids sequence are responsible for the pituitary gland stimulation. Hence, the GHRH analogue is designated as a potential diagnostic target for various growth hormone deficiency disorders. The molecular weight and formula is 3357.96 and C149H246N44O42S, respectively.
The arcuate neurons are part of the hypothalamo-hypophyseal portal system, which is important in releasing the GH in pulsatile version. Somatostatin inhibits the production of GH from the anterior lobe of the pituitary gland; however, an increase in the amount of Sermorelin promotes more GH pulses, which increases its amount. The action of Sermorelin through the PLC pathway requires calcium ions and sodium ions, when GHRH binds to secretin type-G-protein coupled receptor, commonly referred to as GHRHR it causes the activation of cyclic adenosine monophosphate dependent pathway and the PLC or phospholipase C pathway. The terminal downstream actions o the cyclic AMP dependent pathway is essential in the up regulation of the transcription factors by the provision of positive feedback mechanisms, which amplifies GH production. The produced growth hormone is stored in secretory vesicles, which in turn releases the hormone when needed. The downstream actions of phospholipase C dependent pathway depend on Na+-voltage and Ca2+ for their release into the bloodstream. Research indicates that GHRH is vital in promoting non rapid eye movement sleep.
Dosage and Usage
Sermorelin, along with the other peptides you will use, comes as a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water (BC water) or sodium chloride meant for injection. Injections can be administered one hour before workout at a dose of 200mcg-300mcg. Normally, Sermorelin injections are taken before bed at around 300mcgs. Of course, as with any GHRH, you will want to use this peptide alongside a GHRP like GHRP-2 or Ipamorelin for maximum release of growth hormone stores. Ideally, though user could still benefit from using a GHRH like CJC 1295 with DAC and a GHRP like Ipamorelin throughout the day and then utilize Sermorelin as a pre-bed timed dose. Do not discount Sermorelin as simply an anti-aging peptide. It can still help promote the growth of lean body mass and increase the availability of IGF-1 in the blood stream.
Sermorelin Chemical Profile
Soluble in water or 1% acetic acid
Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18°C. Upon reconstitution of the peptide it should be stored at 4°C between 2-21 days and for future use below -18°C.
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