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Bodybuilding Supplements Polypeptide Hormones CAS:170851-70-4 Ipamorelin for Muscle Gain
Ipamorelin, also called as NNC 26-0161, is a pentapeptide, Ghrelin receptor agonist and selective secretagogue of growth hormones. The short chain peptide contains 5 amino acids with long half-life. Ipamorelin demonstrated significant growth hormone releasing capability in experimental studies including in vivo and in vitro. The action of Ipamorelin mimics GHRP-6, promotes growth hormone release from the pituitary cells by acting on GHRP-like receptors. Studies suggest that the compound did not influence cortisol or ACTH levels. Ipamorelin is being studied extensively by the biomedical researchers due to high specificity. The molecular weight and formula of Ipamorelin is 711.85 and C38H49N9O5. Just like GHRP-2 and GHRP-6, ipamorelin suppresses the action of somatostatin and stimulate the production and secretion of GH. Ipamorelin the third generation of the GHRPs , however it is more enhanced than its predecessors and has a longer half life.
Research indicates that ipamorelin mainly acts by activating specific G-protein secretagogues, which in turn increases gastric emptying and gastric motility. The major target for the hormone is the anterior lobe of the pituitary gland where it induces the release of growth hormone, recent studies shows that the hormone has no effect on the level of luteinizing hormone, PRL, follicle stimulating hormone and thyroid stimulating hormone. The GRLN receptor is responsible for the activation of tiny molecules on the pituitary gland, which in turn brings the release of growth hormone. Ipamorelin is known to act on the same receptor that GH acts on, however somatostatin hinders the production and secretion of GH since they are produced in pulses. An increase in the concentration of the polypeptide allows the hormone to be produced in a continuous flow and therefore inducing cell division, proliferation, differentiation, development and maturity thereby bringing about growth and development. D-Lys3-GHRP-6 is the only antagonist to the hormone since it denatures receptor sites therefore the hormone cannot bind to the desired ligand.
Ipamorelin has been shown to be both highly potent and very selective in vivo and vitro situations, and has also demonstrated good safety and tolerability in human clinical studies. Research has shown that Ipamorelin is hormone specific which means that the pituitary hormones such as cortisol are unaffected. In one study, it was found that young female adult rats had increased bone mass due to 12 weeks of treatment with ipamorelin. This peptide compared to other Hormone Releasing Peptides ensures the benefits without having to deal with possible negative side effects.
The Ipamorelin Releasing Peptide Comparison:
Ipamorelin is a 3rd generation GHRP behind GHRP-6 and GHRP-2. Ipamorelin has very similar characteristics of GHRP-2: does not have ghrelin's lipogenic properties and does not promote hunger. Ipamorelin acts synergistically when applied during a Releasing Hormone (GHRH) pulse or when it is administered along with a GHRH or an analog such as Sermorelin or Modified GRF 1-29 (growth releasing factor, aminos 1-29). The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH. On the other hand, Ipamorelin is similar to GHRP-6 because they both release GH at a very similar strength minus the side effects that of GHRP-6. Both GHRP-6 and GHRP-2 cause a release and an increase in cortisol and prolactin levels, however Ipamorelin only selectively releases GH at any dose. Ipamorelin shares similar functionality to Hexarelin and compared to other peptides, it is a much more stable form of ghrelin and has longer half-life periods of at least two hours long and causes secondary effect by making neurons to become excited.
Ipamorelin Chemical Profile
Alias : 696: PN:WO2004005342 PAGE: 46 claimed protein, Ipamorelin, NNC 26-0161
Appearance: White powder
Grade : Pharmaceutical Grade
Usage :Growth hormone secretagogue receptor is a G protein-coupled receptorthat binds ghrelin and plays a role in energy homeostasis and regulation of bodyweight.
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.
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