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ACE-031 1mg

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ACE-031 (ACVR2B) 1mg Polypeptide Hormones Myostatin Inhibitor ACE 031 for Muscle Growth

General information:

ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research studies. ACE-031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, cardiovascular anomalies, age-related muscle loss, and cancer treatment related muscle loss and neuromuscular diseases. ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.

ACE-031 belongs to class of proteins of TGF-beta super family that regulate muscle growth. ACE-031 acts on the molecular switches of these molecules and promote muscle growth. In experimental studies, ACE-031 promotes muscle growth and inhibits ActRIIB receptor signaling. In pre-clinical studies, administration of ACE-031 for two weeks increased skeletal muscle density, decreased leptin levels, and increased adiponectin.

Some bodybuilders use ACE-031 to promote muscle growth and to improve lean muscle. No serious adverse events were reported after ACE-031. Most of the common adverse events are mild and tolerable. The polypeptide contains 368 amino acid molecules, which forms a very large polypeptide complex. Muscle growth is regulated by the production of amino acids , and TGF beta protein super family is mainly the regulator as indicated earlier the on and off switch mechanism is essential for muscle production. When ActRIIB receptors interact with the GDF-8, it sends an on signal, which in turn promotes muscle growth. 

What is ACE-031?

ACE-031 is an investigational (experimental) drug that is designed to increase muscle size and strength by blocking proteins that slow down muscle growth. ACE-031 is a protein drug that is administered by subcutaneous injection.

How does ACE-031 work on muscle?

Muscle growth is regulated by proteins in the body that serve as “on” or “off” switches for muscle production. ACE-031 acts by reducing the “off” signal that stops muscle production, thus muscles may become larger and stronger.

Why is ACE-031 being studied in Duchenne Muscular Dystrophy (DMD)?

ACE-031 may promote muscle growth and improve muscle quality, which may compensate for loss of muscle strength and function due to disease-related muscle damage that occurs in DMD. Because it acts on muscle, ACE-031 has the potential to treat all DMD patients, regardless of their type of dystrophin mutation.

What does ACE-031 do in animal models of DMD?

In animal studies, including healthy animals and animal models of DMD, ACE-031 has been shown to increase the size of muscles and decrease the amount of abnormal scarring in muscle. ACE-031 has also been shown to increase the protein utrophin, which may partially make up for the lack of dystrophin, which causes DMD. The significance of this effect on utrophin is not yet known.

Advantage:

1. Method of Analysis for testing our materials are validated to give the re-producible results
2. All the analytical test procedures and manufacturing procedures are well documented and revision is undertaken as per specified protocol.
3. Trend analysis of purified water and final products are maintained.
4. Stability study is a very important area of quality assuance.
5. Paid orders are processed and despatched the same day and delivered within 5-8 working days worldwide.
6. For your convenience, we use discreet packaging and orders are delivered by post and our delivery success rate is 98%.
7. Should you not receive your order for any reason after 20 working days, please contact us where we will be able to assist you locating your order and if it appears tobe lost in the post, we then will then re-send you a replacement immediately.

Packaging and delivery:

1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking code are provided within 12 hours as soon as receiving the payment. Updated tracking information will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product, please feel free to contact us. Problems would be solved immediately.

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