Coluracetam CAS:135463-81-9

Coluracetam

Product Details:

Place of Origin:CHINA
Brand Name:Hezhong
Certification:ISO9001
Model Number:Coluracetam CAS:135463-81-9

Payment & Shipping Terms:

Minimum Order Quantity:10g
Price:negotiable
Packaging Details:foil bag or as required
Delivery Time:3-5 work days
Payment Terms:T/T, Western Union, MoneyGram, Bitcoin
Supply Ability:100kg/month
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Coluracetam 135463-81-9 White Crystalline Powder Improving Memory Raw Material

 

General information:

Product Name: Coluracetam
Synonyms: MKC-231 BCI-540
CAS: 135463-81-9
MF: C19H23N3O3
MW: 341.4
Manufacturer:HKGC
Assay:99%
Product Categories: Amines;Heterocycles;Intermediates & Fine
Use:Chemicals;Pharmaceuticals;NUPERCAINAL;Other APIs
Packing:Foil bag or as requirments
 

Description:

 
Coluracetam (code name BCI-540; formerly MKC-231) is a nootropic agent of the racetam family.It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently out-licensing the drug for this purpose. It may also have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury.
Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.
 
Coluracetam a nootropic agent composed of a Racetam compound synthetically derived from Piracetam. It is also soluble ethanol. It was first developed and tested in Japan by Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease in 2005. It was then made available to the general public in 2013 and quickly gained recognition for its cognitive effects.
When in action, Coluracetam improves the body’s choline uptake through the high affinity choline uptake (HACU) process; the mechanism for absorbing and converting choline into neurons during the Acetylcholine synthesis process. By facilitating the conversion of large amounts of choline into Acetylcholine, the brain memory, alertness and attention is improved. Coluracetam also affects sections of the brain that are concerned with visual processing, and is therefore touted to improve the sense of sight.

 

Benefits of Coluracetam:

 

According to BrainCells Inc, Coluracetam is a potential treatment for various diseases and disorders that affect the brain and nervous system. Such diseases and disorders that Coluracetam has the potential of treating and preventing include; ischemic retinopathy and optic nerve injuries. The ability of Coluracetam to reverse the loss of choline production makes it a potential drug for treatment of schizophrenia. These refer to the clinical benefits of Coluracetam.
 
Coluracetam also has various other benefits that are not clinical. It is helpful in enhancing cognition, improving the memory and better decision making; it does this by increasing choline uptake and synthesis of Acetylcholine. It is also able to reduce cytotoxicity (a state of being toxic to body cells) of the brain, which is usually caused by an influx of calcium in cultured cortical neurons. This occurs when supply of oxygen to the brain is limited. Coluracetam is also an anti-depressant and can therefore be used in treating various forms of depression. It can be effectively used to deal with stress and hangovers by creating feelings of contentment and peace. This is a motivation boosting nootropic, a distinct feature from the other nootropics. Another unique benefit of Coluracetam is that it is beneficial for eyesight. It improves visual recognition and color vision. Coluracetam has also been found to be effective in the treatment of patients experiencing major depressive disorder and general anxiety disorder making this nootropic supplement an effective anti-depressant.
 
A unique feature of Coluracetam as a nootropic that makes it distinct is that it is the only high affinity choline uptake (HACU) enhancer. This enables it to speed up the flow of Acetylcholine in the brain thereby improving the brain functions of memory, mood, intelligence and learning.
 
The dosage for Coluracetam may not have a medically recommended standard, but a maximum of 200 mg a day is advisable. The dosage also varies depending on the reason for using the supplement. For instance, users taking the supplement to treat major depressive disorder or general anxiety disorder are advised to take 300 mg a day in order to get the maximum benefits.
 
The use of Coluracetam is relatively safe with very few side effects. The common side effect that may be experienced is headaches. This can however be countered by stacking Coluracetam with Centrophenoxine, Alpha GPC, or CDP Choline to reduce such side effects.
 

COA of Coluracetam:

 
Product Name
Coluracetam
Analysis Test
Specification
Result
Description
White crystalline powder, odorless
Conform
Solubility
Easily soluble in water, unsoluble in ethanol
Conform
PH
6.0~7.5
6.9
Solution clarity and color
Solution should be clear and colorless
Conform
Related substances
5'CMP 0.3%
Simple impurity
Total other impurity
0.01%
0.03%
0.10%
Chloride
0.05%
Conform
Ammonium
0.05%
Conform
Fe
0.01%
Conform
Phosphate
0.1%
Conform
Loss on drying
≤6.0%
1.3%
Heavy metals
0.002%
Conform
Arsenide
0.0001%
Conform
Bacterial Endotoxins
0.3EU/mg
Conform
Microbial Limit
Conform
Conform
Assay (on dried basis)
≥99.0%
99.8%
 

 

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Advantage:
1. Method of Analysis for testing our materials are validated to give the re-producible results
2. All the analytical test procedures and manufacturing procedures are well documented and revision is undertaken as per specified protocol.
3. Trend analysis of purified water and final products are maintained.
4. Stability study is a very important area of quality assuance.
5. Paid orders are processed and despatched the same day and delivered within 5-8 working days worldwide.
6. For your convenience, we use discreet packaging and orders are delivered by post and our delivery success rate is 98%.
7. Should you not receive your order for any reason after 20 working days, please contact us where we will be able to assist you locating your order and if it appears tobe lost in the post, we then will then re-send you a replacement immediately.
 
Packaging and delivery:

1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking code are provided within 12 hours as soon as receiving the payment. Updated tracking information will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product, please feel free to contact us. Problems would be solved immediately.
 

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